Andrew C Melton Selected Research

BMN 250

1/2020

Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.

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Andrew C Melton Research Topics

Disease

2	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2023 - 01/2022
2	Autoimmune Diseases (Autoimmune Disease) 01/2013 - 12/2010
2	Inflammation (Inflammations) 03/2012 - 12/2009
2	Fibrosis (Cirrhosis) 12/2009 - 01/2006
1	Cognitive Dysfunction 01/2022
1	Hepatomegaly 01/2022
1	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2022
1	Atrophy 01/2022
1	Rare Diseases (Rare Disease) 01/2020
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 12/2019
1	Disease Progression 12/2019
1	Respiratory Hypersensitivity 03/2012
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2010
1	Lung Injury 12/2009
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2009
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2007
1	Colitis 09/2007

Drug/Important Bio-Agent (IBA)

2	alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA 01/2023 - 01/2020
2	EnzymesIBA 01/2020 - 12/2019
2	CytokinesIBA 01/2013 - 03/2012
2	Interleukin-17 (Interleukin 17)IBA 01/2013 - 03/2012
2	IntegrinsIBA 03/2012 - 12/2010
1	Proteins (Proteins, Gene)FDA Link 01/2023
1	Insulin-Like PeptidesIBA 01/2023
1	GlycosaminoglycansIBA 01/2022
1	BMN 250IBA 01/2020
1	Tripeptidyl-Peptidase 1IBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 12/2019
1	AntibodiesIBA 01/2013
1	AllergensIBA 03/2012
1	OvalbuminIBA 03/2012
1	CollagenIBA 12/2009
1	Glycoproteins (Glycoprotein)IBA 12/2009
1	Epidermal Growth Factor (EGF)IBA 12/2009
1	milk fat globuleIBA 12/2009
1	Bleomycin (Blenoxane)FDA LinkGeneric 12/2009
1	Transforming Growth Factor beta (TGF-beta)IBA 09/2007
1	Integrin alphaVIBA 09/2007
1	Endothelin-1 (Endothelin 1)IBA 01/2006

Therapy/Procedure

3	Enzyme Replacement Therapy 01/2023 - 01/2020
2	Therapeutics 01/2023 - 01/2022